Chiasmata formed during prophase I provide a physical link that holds homologs in pairs facilitating their orientation on the spindle at meiosis I. Consequently, mutations that cause loss or misregulation in the number and position of COs are invariably associated with increased errors in meiotic chromosome segregation and the generation of aneuploid gametes. However, in yeast and flies, it has been shown that these error prone chromosomes do not segregate randomly. Instead, a high proportion of them partition correctly. Intriguingly, in yeast, it has been demonstrated that pairing between the centromeres – centromere pairing – promotes the proper segregation of these non-recombined meiotic chromosomes (Figure 3) and also contributes significantly to the segregation fidelity of chromosomes that have recombined. It may be that centromere pairing provides an alternative mechanism for promoting proper meiotic segregation by linking the homologous centromeres in a way that promotes their proper attachment to microtubules from opposite poles of the meiosis I spindle. We recently reported the first studies of centromere pairing in a higher eukaryote. Our efforts identified previously unrecognized roles for synaptonemal complex components in the formation and maintenance of centromere pairing. We observed that SYCP1 and SYCP3 are retained at paired centromeres after their removal from chromosome arms, and are required for persistent homologous centromere pairing (Figure 3).